Work to upgrade safety barriers on the A41 between the Ludgershall and Piddington junctions will start on Monday, February 11.
The work is due to be completed in about four weeks.
It will involve protecting the weak bridge railings at Ivy House Bridge, near Leaches Farm Business Centre, and the installation of a new safety barrier between the carriageway and bridge railings.
Temporary traffic lights will be in use across the bridge from Monday to Friday, from 9.30am to 3.30pm.
For more information, contact Transport for Buckinghamshire on 0845 2302882.