The route from Bicester Town rail station to Oxford will be closed from Saturday, February 15 while a track to link Oxford, Bicester Town and London is built.
A replacement bus service will be running instead of the rail service, which will travel along the A43 and will stop at Islip.
It is expected that the building work on the £130 million link between Oxford and London Marylebone will take around 18 months to complete as Chiltern Railways seeks to provide fast and frequent commuter services between the three locations.
The plans are part of Chiltern Railways’ Evergreen 3 Project, which has overseen the development of improved rail travel between Birmingham, Bicester and London.
These latest developments will see Bicester Town station being rebuilt with a second platform, which, along with the existing platform will be longer.
There will also be an accessible footbridge with lifts or ramps and new station buildings, complete with extra car parking facilities and extra customer information systems.
The new link is expected to complement the proposed East-West Rail link connecting Oxford and Milton Keynes via Bicester and Winslow.
Regular travellers on the service to Oxford from Bicester can find out more information on schedule changes on Chiltern Railway’s online system at chilternrailways.co.uk.
Commuters are also advised to check times regularly in case of any minor changes.