A crash which involved up to 40 vehicles happened this morning on the M40 near Bicester.
The massive pile-up happened at around 8am between junctions nine and ten.
One person has died, one person suffered life threatening injuries and six people have serious injuries. A further 35 people sustained minor injuries in the crash.
All the injured have been taken to the John Radcliffe Hospital in Oxford.
The motorway is closed northbound between the junctions and is expected to remain closed throught the day.
Inspector Daren Courtenay, from the Joint Operations Unit for Roads Policing said: “Officers are currently on the scene attending the ongoing incident.
“The northbound carriageway is currently closed and is expected to remain closed for a number of hours. The southbound carriageway is open however restrictions are in place so delays should be expected.
“I would request drivers find an alternative route and would like to advise motorists to take extra care as there is fog in the area.”
More updates as we get them.